{"entity":{"id":"gadoteridol","kind":"drug","name":"Gadoteridol","aka":["gadoteridol","ProHance"],"tldr":"An MRI dye given into a vein for scans of the brain, spine, and head and neck.","summary":"Bracco's ProHance (NDA 020131, first approved 16 November 1992) is indicated for MRI to visualise \"lesions with disrupted blood brain barrier and/or abnormal vascularity in the brain (intracranial lesions), spine and associated tissues\" in adults and children including term neonates, and \"lesions in the head and neck in adults\". ATC V08CA04. Like every gadolinium-based contrast agent in the United States, its label carries a boxed warning on the risks of intrathecal use and nephrogenic systemic fibrosis, a thickening of skin and organs seen in people with severe kidney disease.","status":"approved","asOf":"2026-11-04","links":[{"label":"Drugs@FDA ProHance (NDA 020131)","url":"https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=020131"},{"label":"DailyMed label: ProHance","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=778aee03-7d4c-481a-be8a-a75db0702f5a"},{"label":"WHO ATC index V08CA: paramagnetic contrast media","url":"https://atcddd.fhi.no/atc_ddd_index/?code=V08CA&showdescription=no"}],"tags":["contrast-agents-gaps-2026-11","diagnostic"],"related":[],"cancers":["glioblastoma","head-and-neck"],"sections":[],"technologies":["gadolinium-based-contrast-agents","mri"],"targets":[],"drugs":[],"companies":["bracco"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo contrast agent gap fill (Drugs@FDA, FDA labels, DailyMed, EMA register, WHO ATC index)","editedOn":"2026-11-04"},"brand":"ProHance","modality":"Gadolinium-based contrast agent for MRI of the brain, spine and head and neck (intravenous)","mechanism":"A gadolinium chelate that brightens tissue on MRI where it leaves the blood.","approvals":[{"region":"US","year":1992,"indication":"MRI of the brain, spine and associated tissues; MRI of the head and neck in adults","note":"NDA 020131; Bracco"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/gadoteridol/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"}],"technology":[{"id":"gadolinium-based-contrast-agents","kind":"technology","name":"Gadolinium-based and other MRI contrast agents","route":"/technologies/gadolinium-based-contrast-agents/"},{"id":"mri","kind":"technology","name":"MRI","route":"/technologies/mri/"}],"company":[{"id":"bracco","kind":"company","name":"Bracco (Bracco Imaging and Bracco Diagnostics)","route":"/companies/bracco/"}]}}