{"entity":{"id":"galnt14","kind":"target","name":"GALNT14","aka":["polypeptide N-acetylgalactosaminyltransferase 14","Polypeptide N-acetylgalactosaminyltransferase 14","GalNac-T10","FLJ12691","GalNac-T14"],"tldr":"GALNT14 (Polypeptide N-acetylgalactosaminyltransferase 14) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.","summary":"Catalyses the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 2 variants.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:22946","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:22946"},{"label":"UniProt Q96FL9","url":"https://www.uniprot.org/uniprotkb/Q96FL9/entry"},{"label":"NCBI Gene 79623","url":"https://www.ncbi.nlm.nih.gov/gene/79623"},{"label":"Ensembl ENSG00000158089","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000158089"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["hcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GALNT14","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:22946","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:22946","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96FL9","url":"https://www.uniprot.org/uniprotkb/Q96FL9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene GALNT14","url":"https://civicdb.org/features/14923","note":"1 evidence items, 0 assertions, 2 variants; diseases: Hepatocellular Carcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:22946","ensembl":"ENSG00000158089","uniprot":"Q96FL9","entrez":"79623","biology":"Catalyses the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney. Location: Golgi apparatus membrane (UniProt). Locus 2p23.1 (HGNC).","whereFound":["Hepatocellular carcinoma: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/galnt14/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}]}}