{"entity":{"id":"gamma-delta-t-cell-therapy","kind":"technology","name":"Gamma-delta T cell therapy","aka":[],"tldr":"Cell therapies built from a rare T-cell type that recognises stressed cancer cells without needing tissue matching, making them candidates for off-the-shelf products.","summary":"Gamma-delta T cells recognise stress ligands and phosphoantigens on tumour cells independently of HLA, so donor cells can be given without matching and without causing graft-versus-host disease. Companies expand the Vδ1 or Vδ2 subsets from healthy donors, sometimes adding a CAR, and early trials in leukaemia, lymphoma and solid tumours are under way. Persistence after infusion and manufacturing scale are the main hurdles.","status":"phase-1","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Gamma_delta_T_cell","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Gamma_delta_T_cell"}],"tags":[],"related":[],"cancers":["aml"],"sections":["cell-therapy"],"technologies":["allogeneic-cell-therapy","car-t"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"principle":"Donor gamma-delta T cells are expanded ex vivo with phosphoantigens or cytokines, optionally engineered with a chimeric antigen receptor, and infused as an allogeneic product.","strengths":["HLA-independent recognition, no graft-versus-host disease","Off-the-shelf potential","Innate-like killing of stressed cells"],"limitations":["Short persistence","Early clinical stage","Expansion yields vary between donors"]},"route":"/technologies/gamma-delta-t-cell-therapy/","neighbours":{"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"}],"section":[{"id":"cell-therapy","kind":"section","name":"Cell Therapy","route":"/fronts/cell-therapy/"}],"technology":[{"id":"allogeneic-cell-therapy","kind":"technology","name":"Allogeneic (off-the-shelf) cell therapy","route":"/technologies/allogeneic-cell-therapy/"},{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"}]}}