{"entity":{"id":"gas6","kind":"target","name":"GAS6","aka":["growth arrest specific 6","Growth arrest-specific protein 6","FLJ34709","DKFZp666G247","AXLLG"],"tldr":"GAS6 (Growth arrest-specific protein 6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.","summary":"Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signalling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signalling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signalling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays a role in Dengue cell entry by apoptotic mimicry.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Docetaxel.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4168","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4168"},{"label":"UniProt Q14393","url":"https://www.uniprot.org/uniprotkb/Q14393/entry"},{"label":"NCBI Gene 2621","url":"https://www.ncbi.nlm.nih.gov/gene/2621"},{"label":"Ensembl ENSG00000183087","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183087"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Oral Squamous Cell Carcinoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GAS6","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:4168","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4168","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q14393","url":"https://www.uniprot.org/uniprotkb/Q14393/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene GAS6","url":"https://civicdb.org/features/2186","note":"2 evidence items, 0 assertions, 1 variants; diseases: Prostate Cancer, Oral Squamous Cell Carcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:4168","ensembl":"ENSG00000183087","uniprot":"Q14393","entrez":"2621","biology":"Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signalling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signalling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signalling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays a role in Dengue cell entry by apoptotic mimicry. Plays a role in Vaccinia virus cell entry by apoptotic mimicry. Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry. Location: Secreted (UniProt). Locus 13q34 (HGNC).","whereFound":["Prostate cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/gas6/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}