{"entity":{"id":"gata3","kind":"target","name":"GATA3","aka":["GATA binding protein 3","Trans-acting T-cell-specific transcription factor GATA-3"],"tldr":"GATA3 (Trans-acting T-cell-specific transcription factor GATA-3) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Non-Hodgkin lymphoma, Leukaemia and 2 more.","summary":"Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cobimetinib. Open Targets scores its association with cancer at 0.78 (direct and indirect evidence; datatypes affected pathway 0.56, literature 0.99, genetic association 0.37, somatic mutation 0.87, animal model 0.65). IntOGen calls it a driver in 7 cohorts (3 activating, 3 loss-of-function), covering Acute Lymphoblastic Leukaemia, Invasive Breast Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4172","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4172"},{"label":"UniProt P23771","url":"https://www.uniprot.org/uniprotkb/P23771/entry"},{"label":"NCBI Gene 2625","url":"https://www.ncbi.nlm.nih.gov/gene/2625"},{"label":"Ensembl ENSG00000107485","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107485"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["breast-cancer","non-hodgkin-lymphoma","leukaemia","hodgkin-lymphoma","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Histiocytosis-Lymphadenopathy Plus Syndrome."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GATA3","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:4172","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4172","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P23771","url":"https://www.uniprot.org/uniprotkb/P23771/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene GATA3","url":"https://civicdb.org/features/2189","note":"1 evidence items, 0 assertions, 1 variants; diseases: Histiocytosis-Lymphadenopathy Plus Syndrome (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000107485","url":"https://platform.opentargets.org/target/ENSG00000107485/associations","note":"association with cancer (MONDO_0004992) 0.78; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.62, Hodgkins lymphoma 0.51, non-Hodgkin lymphoma 0.66, breast cancer 0.74, leukaemia 0.66 (GraphQL API, CC0)"},{"label":"IntOGen GATA3","url":"https://www.intogen.org/search?gene=GATA3","note":"driver in 7 cohorts (Act 3, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:4172","ensembl":"ENSG00000107485","uniprot":"P23771","entrez":"2625","biology":"Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression. Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signalling to drive differentiation of inflammation-resolving alternatively activated macrophages. Location: Nucleus (UniProt). Locus 10p14 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.74 with breast cancer (MONDO_0007254); IntOGen driver in 6 cohorts (BRCA)","Non-Hodgkin lymphoma: Open Targets association 0.66 with non-Hodgkin lymphoma (MONDO_0018908)","Leukaemia: Open Targets association 0.66 with leukaemia (MONDO_0005059)","Hodgkin lymphoma: Open Targets association 0.51 with Hodgkins lymphoma (MONDO_0004952)","Acute lymphoblastic leukaemia: Open Targets association 0.62 with acute lymphoblastic leukaemia (MONDO_0004967); IntOGen driver in 1 cohort (ALL)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/gata3/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"hodgkin-lymphoma","kind":"cancer","name":"Hodgkin lymphoma","route":"/cancers/hodgkin-lymphoma/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}