{"entity":{"id":"gdf7","kind":"target","name":"GDF7","aka":["growth differentiation factor 7","Growth/differentiation factor 7","BMP12"],"tldr":"GDF7 (Growth/differentiation factor 7) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"May play an active role in the motor area of the primate neocortex.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.67, animal model 0.71, genetic association 0.80).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4222","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4222"},{"label":"UniProt Q7Z4P5","url":"https://www.uniprot.org/uniprotkb/Q7Z4P5/entry"},{"label":"NCBI Gene 151449","url":"https://www.ncbi.nlm.nih.gov/gene/151449"},{"label":"Ensembl ENSG00000143869","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143869"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GDF7","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:4222","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4222","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q7Z4P5","url":"https://www.uniprot.org/uniprotkb/Q7Z4P5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000143869","url":"https://platform.opentargets.org/target/ENSG00000143869/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"hgnc":"HGNC:4222","ensembl":"ENSG00000143869","uniprot":"Q7Z4P5","entrez":"151449","biology":"May play an active role in the motor area of the primate neocortex. Location: Secreted (UniProt). Locus 2p24.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/gdf7/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}