{"entity":{"id":"gim-122","kind":"drug","name":"GIM-122","aka":["GIM122"],"tldr":"GIM-122 is an experimental humanised IgG1 kappa dual-functioning monoclonal antibody from Georgiamune, in phase 1 trials for advanced solid malignancies.","summary":"GIM-122 (GIM122) is a humanised IgG1 kappa dual-functioning monoclonal antibody from Georgiamune. A dual-functioning antibody that the company says overcomes cancer-mediated immune suppression and at the same time stimulates activated T cells; targets not disclosed. Its furthest stage is phase 1, for advanced solid malignancies. ClinicalTrials.gov registers it in one study linked below. FDA IND clearance August 2023; phase 1/2 recruiting per registry (NCT06028074). Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Georgiamune: georgiamune.com","url":"https://www.georgiamune.com/pipeline"},{"label":"Georgiamune: clinicaltrials.gov","url":"https://clinicaltrials.gov/study/NCT06028074"},{"label":"ClinicalTrials.gov: trials of GIM-122","url":"https://clinicaltrials.gov/search?intr=GIM-122"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["georgiamune"],"institutions":[],"pathways":[],"terms":[],"trials":["nct06028074"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"GIM-122","modality":"Humanised IgG1 kappa dual-functioning monoclonal antibody","mechanism":"A dual-functioning antibody that the company says overcomes cancer-mediated immune suppression and at the same time stimulates activated T cells; targets not disclosed.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/gim-122/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"company":[{"id":"georgiamune","kind":"company","name":"Georgiamune","route":"/companies/georgiamune/"}],"trial":[{"id":"nct06028074","kind":"trial","name":"Safety and Tolerability Study of GIM-122 in Subjects With Advanced Solid Malignancies","route":"/trials/nct06028074/"}]}}