{"entity":{"id":"gistic","kind":"term","name":"GISTIC (copy number driver detection)","aka":["GISTIC","GISTIC2","GISTIC2.0","GISTIC peaks","GISTIC score"],"tldr":"GISTIC scans copy number data across many tumours to find the regions that are amplified or deleted far more often than chance, the likely targets of selection.","summary":"GISTIC2.0, from Mermel and colleagues at the Broad Institute, facilitates sensitive and confident localisation of the targets of focal somatic copy number alteration by scoring each genomic region on the frequency and amplitude of alteration across a cohort and assigning a false-discovery q-value; it distinguishes arm-level from focal events and reports peak regions. TCGA copy number papers report GISTIC peaks, and the gene-level thresholded calls (deep deletion, amplification) on cBioPortal come from it. The Broad distributes it under a research licence, so OnCo's open-source map lists it as skipped.","asOf":"2026-09-24","links":[{"label":"GISTIC2 documentation (Broad Institute)","url":"https://broadinstitute.github.io/gistic2/"},{"label":"Mermel et al., GISTIC2.0 (Genome Biology 2011)","url":"https://doi.org/10.1186/gb-2011-12-4-r41"}],"tags":["cansim-terms"],"related":["intogen","cancer-ai-vocabulary"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["copy-number-variation-term","mutsig"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Listed in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme; CanSim page path /terms/gistic."],"provenance":{"editedBy":"OnCo CanSim terms wave (Wikipedia summaries, standards and project pages, GDC and FDA pages, Europe PMC)","editedOn":"2026-09-24","note":"CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme"},"category":"Genomics & genetics"},"route":"/terms/gistic/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"term":[{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"copy-number-variation-term","kind":"term","name":"Copy number alteration (CNA)","route":"/terms/copy-number-variation-term/"},{"id":"mutsig","kind":"term","name":"MutSig (significantly mutated gene detection)","route":"/terms/mutsig/"}]}}