{"entity":{"id":"globeimmune","kind":"company","name":"GlobeImmune","aka":["GlobeImmune, Inc."],"tldr":"GlobeImmune is a Colorado biotech that used whole heat-killed yeast to deliver tumour antigens to the immune system; GI-6301 carried the transcription factor brachyury for chordoma and other cancers.","summary":"GlobeImmune developed Tarmogens, heat-killed recombinant Saccharomyces cerevisiae yeast engineered to express disease antigens, which are taken up by dendritic cells and drive antigen-specific T-cell responses. GI-6301 expresses brachyury, a transcription factor that drives epithelial-to-mesenchymal transition and is the defining marker of chordoma; it was studied with radiotherapy in a randomised phase 2 chordoma trial run with the National Cancer Institute. GI-4000, targeting mutant RAS, was tested in pancreatic cancer and lung cancer.","asOf":"2026-09-17","links":[],"tags":["drug-maker"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":["gi-6301"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo drug-maker linking round (corporate websites and regulatory records)","editedOn":"2026-09-17"},"hq":"Louisville, Colorado","country":"US","companyType":"biotech","founded":1995,"investors":[],"funding":[]},"route":"/companies/globeimmune/","neighbours":{"drug":[{"id":"gi-6301","kind":"drug","name":"GI-6301","route":"/drugs/gi-6301/"}]}}