{"entity":{"id":"glytr1","kind":"drug","name":"GlyTR1","aka":[],"tldr":"GlyTR1 is an experimental protein from GlyTR Therapeutics that latches onto sugar molecules crowded on cancer cells and pulls immune T cells in to attack. It has been tested only in the laboratory and in animals.","summary":"GlyTR1 is a bispecific Glycan-dependent T cell Recruiter developed by GlyTR Therapeutics from work at the University of California, Irvine. It binds beta1,6GlcNAc-branched N-glycans through a lectin domain and engages T cells through CD3. The NIH RePORTER abstract for STTR award 4R42CA302415-02 describes GlyTR1 and GlyTR2 as killing cells with high but not low expression of tumour-associated carbohydrate antigens in preclinical models; there are no human results.","status":"preclinical","asOf":"2026-11-04","links":[{"label":"GlyTR Therapeutics: news","url":"https://glytrtherapeutics.com/news/"},{"label":"NIH RePORTER: STTR award 4R42CA302415-02","url":"https://reporter.nih.gov/project-details/11457445"}],"tags":["pipeline"],"related":[],"cancers":[],"sections":[],"technologies":["t-cell-engager"],"targets":["cd3"],"drugs":[],"companies":["glytr-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo startup monitors","editedOn":"2026-11-04"},"code":"GlyTR1","modality":"Bispecific T-cell engager (lectin domain fused to anti-CD3)","mechanism":"A Glycan-dependent T cell Recruiter: a lectin domain binds beta1,6GlcNAc-branched N-glycans, which are dense on many cancer cells, and an anti-CD3 domain brings T cells to kill them.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/glytr1/","neighbours":{"technology":[{"id":"t-cell-engager","kind":"technology","name":"T-cell engagers (bispecific)","route":"/technologies/t-cell-engager/"}],"target":[{"id":"cd3","kind":"target","name":"CD3","route":"/targets/cd3/"}],"company":[{"id":"glytr-therapeutics","kind":"company","name":"GlyTR Therapeutics","route":"/companies/glytr-therapeutics/"}]}}