{"entity":{"id":"gmps","kind":"target","name":"GMPS","aka":["guanosine monophosphate synthase","GMP synthase [glutamine-hydrolyzing]","GATD7"],"tldr":"GMPS (GMP synthase [glutamine-hydrolysing]) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma.","summary":"Catalyses the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Hepatocellular Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4378","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4378"},{"label":"UniProt P49915","url":"https://www.uniprot.org/uniprotkb/P49915/entry"},{"label":"NCBI Gene 8833","url":"https://www.ncbi.nlm.nih.gov/gene/8833"},{"label":"Ensembl ENSG00000163655","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163655"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["hcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GMPS","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:4378","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4378","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P49915","url":"https://www.uniprot.org/uniprotkb/P49915/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen GMPS","url":"https://www.intogen.org/search?gene=GMPS","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:4378","ensembl":"ENSG00000163655","uniprot":"P49915","entrez":"8833","biology":"Catalyses the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate. Location: Cytoplasm, cytosol (UniProt). Locus 3q25.31 (HGNC).","whereFound":["Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/gmps/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}]}}