{"entity":{"id":"gnb1","kind":"target","name":"GNB1","aka":["G protein subunit beta 1","Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1"],"tldr":"GNB1 (Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.","summary":"Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signalling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction.\n\n","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4396","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4396"},{"label":"UniProt P62873","url":"https://www.uniprot.org/uniprotkb/P62873/entry"},{"label":"NCBI Gene 2782","url":"https://www.ncbi.nlm.nih.gov/gene/2782"},{"label":"Ensembl ENSG00000078369","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000078369"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","non-hodgkin-lymphoma","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GNB1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:4396","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4396","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P62873","url":"https://www.uniprot.org/uniprotkb/P62873/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000078369","url":"https://platform.opentargets.org/target/ENSG00000078369/associations","note":"per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.55, non-Hodgkin lymphoma 0.55, leukaemia 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:4396","ensembl":"ENSG00000078369","uniprot":"P62873","entrez":"2782","biology":"Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signalling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Locus 1p36.33 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.55 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.55 with non-Hodgkin lymphoma (MONDO_0018908)","Acute lymphoblastic leukaemia: Open Targets association 0.55 with acute lymphoblastic leukaemia (MONDO_0004967)"],"targetClass":"other","prevalence":[]},"route":"/targets/gnb1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}