{"entity":{"id":"golga4","kind":"target","name":"GOLGA4","aka":["golgin A4","Golgin subfamily A member 4","golgin-245","GCP2","p230","golgin-240"],"tldr":"GOLGA4 (Golgin subfamily A member 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.68, affected pathway 0.76, genetic association 0.38).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4427","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4427"},{"label":"UniProt Q13439","url":"https://www.uniprot.org/uniprotkb/Q13439/entry"},{"label":"NCBI Gene 2803","url":"https://www.ncbi.nlm.nih.gov/gene/2803"},{"label":"Ensembl ENSG00000144674","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000144674"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GOLGA4","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:4427","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4427","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13439","url":"https://www.uniprot.org/uniprotkb/Q13439/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000144674","url":"https://platform.opentargets.org/target/ENSG00000144674/associations","note":"association with cancer (MONDO_0004992) 0.54;  (GraphQL API, CC0)"}],"hgnc":"HGNC:4427","ensembl":"ENSG00000144674","uniprot":"Q13439","entrez":"2803","biology":"Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking. Location: Cytoplasm; Golgi apparatus membrane; Golgi apparatus, trans-Golgi network membrane (UniProt). Locus 3p22.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/golga4/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}