{"entity":{"id":"golga5","kind":"target","name":"GOLGA5","aka":["golgin A5","Golgin subfamily A member 5","ret-II","golgin-84","rfg5","GOLIM5"],"tldr":"GOLGA5 (Golgin subfamily A member 5) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.","summary":"Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.10, genetic association 0.00, somatic mutation 0.92).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4428","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4428"},{"label":"UniProt Q8TBA6","url":"https://www.uniprot.org/uniprotkb/Q8TBA6/entry"},{"label":"NCBI Gene 9950","url":"https://www.ncbi.nlm.nih.gov/gene/9950"},{"label":"Ensembl ENSG00000066455","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000066455"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GOLGA5","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:4428","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4428","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8TBA6","url":"https://www.uniprot.org/uniprotkb/Q8TBA6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000066455","url":"https://platform.opentargets.org/target/ENSG00000066455/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"}],"hgnc":"HGNC:4428","ensembl":"ENSG00000066455","uniprot":"Q8TBA6","entrez":"9950","biology":"Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. Location: Golgi apparatus membrane (UniProt). Locus 14q32.12 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/golga5/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}