{"entity":{"id":"gopc","kind":"target","name":"GOPC","aka":["golgi associated PDZ and coiled-coil motif containing","Golgi-associated PDZ and coiled-coil motif-containing protein","dJ94G16.2","GOPC1"],"tldr":"GOPC (Golgi-associated PDZ and coiled-coil motif-containing protein) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.","summary":"Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.31, animal model 0.39, genetic association 0.04, somatic mutation 0.92).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:17643","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17643"},{"label":"UniProt Q9HD26","url":"https://www.uniprot.org/uniprotkb/Q9HD26/entry"},{"label":"NCBI Gene 57120","url":"https://www.ncbi.nlm.nih.gov/gene/57120"},{"label":"Ensembl ENSG00000047932","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000047932"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GOPC","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:17643","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17643","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9HD26","url":"https://www.uniprot.org/uniprotkb/Q9HD26/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000047932","url":"https://platform.opentargets.org/target/ENSG00000047932/associations","note":"association with cancer (MONDO_0004992) 0.58;  (GraphQL API, CC0)"}],"hgnc":"HGNC:17643","ensembl":"ENSG00000047932","uniprot":"Q9HD26","entrez":"57120","biology":"Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR. Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes. Location: Cytoplasm; Golgi apparatus membrane; Golgi apparatus, trans-Golgi network membrane; Synapse (UniProt). Locus 6q22.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/gopc/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}