{"entity":{"id":"gpaa1","kind":"target","name":"GPAA1","aka":["glycosylphosphatidylinositol anchor attachment 1","GPI-anchor transamidase component GPAA1","GAA1","hGAA1"],"tldr":"GPAA1 (GPI-anchor transamidase component GPAA1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.","summary":"Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyses the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Binds GPI-anchor.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Bladder Urothelial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4446","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4446"},{"label":"UniProt O43292","url":"https://www.uniprot.org/uniprotkb/O43292/entry"},{"label":"NCBI Gene 8733","url":"https://www.ncbi.nlm.nih.gov/gene/8733"},{"label":"Ensembl ENSG00000197858","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197858"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["urothelial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GPAA1","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:4446","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4446","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O43292","url":"https://www.uniprot.org/uniprotkb/O43292/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen GPAA1","url":"https://www.intogen.org/search?gene=GPAA1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:4446","ensembl":"ENSG00000197858","uniprot":"O43292","entrez":"8733","biology":"Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyses the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Binds GPI-anchor. Location: Endoplasmic reticulum membrane (UniProt). Locus 8q24.3 (HGNC).","whereFound":["Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/gpaa1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"}]}}