{"entity":{"id":"gpc5","kind":"target","name":"GPC5","aka":["glypican 5","Glypican-5"],"tldr":"GPC5 (Glypican-5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Ovarian cancer and Biliary tract cancer.","summary":"Cell surface proteoglycan that bears heparan sulfate.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.54, somatic mutation 0.43). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Cholangiocarcinoma, Ovarian Epithelial Tumour.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4453","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4453"},{"label":"UniProt P78333","url":"https://www.uniprot.org/uniprotkb/P78333/entry"},{"label":"NCBI Gene 2262","url":"https://www.ncbi.nlm.nih.gov/gene/2262"},{"label":"Ensembl ENSG00000179399","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000179399"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["ovarian","cholangiocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GPC5","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:4453","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4453","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P78333","url":"https://www.uniprot.org/uniprotkb/P78333/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000179399","url":"https://platform.opentargets.org/target/ENSG00000179399/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"},{"label":"IntOGen GPC5","url":"https://www.intogen.org/search?gene=GPC5","note":"driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:4453","ensembl":"ENSG00000179399","uniprot":"P78333","entrez":"2262","biology":"Cell surface proteoglycan that bears heparan sulfate. Location: Cell membrane; Secreted, extracellular space (UniProt). Locus 13q31.3 (HGNC).","whereFound":["Ovarian cancer: IntOGen driver in 1 cohort (OVT)","Biliary tract cancer: IntOGen driver in 1 cohort (CHOL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/gpc5/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"cholangiocarcinoma","kind":"cancer","name":"Biliary tract cancer (cholangiocarcinoma)","route":"/cancers/cholangiocarcinoma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}