{"entity":{"id":"grb7","kind":"target","name":"GRB7","aka":["growth factor receptor bound protein 7"],"tldr":"GRB7 is an adaptor protein gene that sits next to HER2 on chromosome 17 and is copied along with it in HER2-positive cancers.","summary":"17q12 HER2 amplicon neighbour: co-amplified and co-expressed with ERBB2 in HER2-positive breast and gastric cancer, so it appears in HER2-enriched expression signatures as a passenger of the amplification rather than a driver of its own. UniProt describes GRB7 as an adapter that interacts with numerous receptor kinases and promotes activation of STAT3, AKT and MAPK; it is one of the genes in the Oncotype DX HER2 group.","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:4567","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4567"},{"label":"UniProt Q14451","url":"https://www.uniprot.org/uniprotkb/Q14451/entry"}],"tags":["cansim-terms"],"related":["her2"],"cancers":["breast-cancer","gastric"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["ras-mapk","pi3k-akt-mtor"],"terms":["co-amplification","cancer-ai-vocabulary"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme."],"provenance":{"editedBy":"OnCo CanSim terms wave (HGNC REST, UniProt REST)","editedOn":"2026-09-24","note":"CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme"},"symbol":"GRB7","role":["biomarker"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:4567","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4567","note":"approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)"},{"label":"UniProt Q14451","url":"https://www.uniprot.org/uniprotkb/Q14451/entry","note":"protein name, function and tissue specificity text (REST API, 2026-09-24)"}],"specificitySources":[],"hgnc":"HGNC:4567","ensembl":"ENSG00000141738","uniprot":"Q14451","entrez":"2886","biology":"Adapter protein that binds the cytoplasmic domain of receptor kinases and modulates downstream signalling, promoting activation of STAT3, AKT1 and MAPK1/3 and of HRAS (UniProt Q14451).","whereFound":["Locus 17q12 (HGNC)."],"targetClass":"other","prevalence":[]},"route":"/targets/grb7/","neighbours":{"target":[{"id":"her2","kind":"target","name":"HER2","route":"/targets/her2/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}],"pathway":[{"id":"pi3k-akt-mtor","kind":"pathway","name":"PI3K / AKT / mTOR","route":"/pathways/pi3k-akt-mtor/"},{"id":"ras-mapk","kind":"pathway","name":"RAS / RAF / MEK / ERK (MAPK)","route":"/pathways/ras-mapk/"}],"term":[{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"co-amplification","kind":"term","name":"Co-amplification and the 17q12 HER2 amplicon","route":"/terms/co-amplification/"}]}}