{"entity":{"id":"grhpr","kind":"target","name":"GRHPR","aka":["glyoxylate and hydroxypyruvate reductase","Glyoxylate reductase/hydroxypyruvate reductase","PH2"],"tldr":"GRHPR (Glyoxylate reductase/hydroxypyruvate reductase) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate, oxidises D-glycerate to hydroxypyruvate.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4570","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4570"},{"label":"UniProt Q9UBQ7","url":"https://www.uniprot.org/uniprotkb/Q9UBQ7/entry"},{"label":"NCBI Gene 9380","url":"https://www.ncbi.nlm.nih.gov/gene/9380"},{"label":"Ensembl ENSG00000137106","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137106"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GRHPR","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:4570","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4570","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UBQ7","url":"https://www.uniprot.org/uniprotkb/Q9UBQ7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene GRHPR","url":"https://civicdb.org/features/7411","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"hgnc":"HGNC:4570","ensembl":"ENSG00000137106","uniprot":"Q9UBQ7","entrez":"9380","biology":"Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate, oxidises D-glycerate to hydroxypyruvate. Locus 9p13.2 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/grhpr/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}