{"entity":{"id":"grm3","kind":"target","name":"GRM3","aka":["glutamate metabotropic receptor 3","Metabotropic glutamate receptor 3","GPRC1C","mGlu3","MGLUR3"],"tldr":"GRM3 (Metabotropic glutamate receptor 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Renal cell carcinoma, Oesophageal cancer, Chromophobe renal cell carcinoma and 2 more.","summary":"G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signalling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signalling inhibits adenylate cyclase activity.\n\nIntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Chromophobe Renal Cell Carcinoma, Oesophageal Adenocarcinoma, Melanoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4595","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4595"},{"label":"UniProt Q14832","url":"https://www.uniprot.org/uniprotkb/Q14832/entry"},{"label":"NCBI Gene 2913","url":"https://www.ncbi.nlm.nih.gov/gene/2913"},{"label":"Ensembl ENSG00000198822","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198822"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["rcc","esophageal","chromophobe-rcc","oesophageal-adenocarcinoma","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GRM3","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:4595","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4595","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q14832","url":"https://www.uniprot.org/uniprotkb/Q14832/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen GRM3","url":"https://www.intogen.org/search?gene=GRM3","note":"driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:4595","ensembl":"ENSG00000198822","uniprot":"Q14832","entrez":"2913","biology":"G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signalling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signalling inhibits adenylate cyclase activity. Location: Cell membrane (UniProt). Locus 7q21.11-q21.12 (HGNC).","whereFound":["Renal cell carcinoma: IntOGen driver in 1 cohort (CHRCC)","Oesophageal cancer: IntOGen driver in 1 cohort (ESCA)","Chromophobe renal cell carcinoma: IntOGen driver in 1 cohort (CHRCC)","Oesophageal and junctional adenocarcinoma: IntOGen driver in 1 cohort (ESCA)","Melanoma: IntOGen driver in 1 cohort (MEL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/grm3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"chromophobe-rcc","kind":"cancer","name":"Chromophobe renal cell carcinoma","route":"/cancers/chromophobe-rcc/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"oesophageal-adenocarcinoma","kind":"cancer","name":"Oesophageal and junctional adenocarcinoma","route":"/cancers/oesophageal-adenocarcinoma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}