{"entity":{"id":"h101-oncolytic-adenovirus","kind":"drug","name":"H101 oncolytic adenovirus","aka":["Oncorine"],"tldr":"Oncorine is Shanghai Sunway Biotech's oncolytic adenovirus, approved in China in 2005 for nasopharyngeal carcinoma with chemotherapy, the first oncolytic virus approved anywhere in the world.","summary":"H101 (Oncorine) is an E1B-55K-deleted adenovirus derived from the same design as ONYX-015, developed by Shanghai Sunway Biotech. The NMPA (then the SFDA) approved it in November 2005 for late-stage nasopharyngeal carcinoma in combination with chemotherapy, ten years before talimogene laherparepvec became the first oncolytic virus approved in the United States. It is injected into the tumour.","status":"approved","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov: trials of H101","url":"https://clinicaltrials.gov/search?intr=H101"}],"tags":["china","nmpa-approved"],"related":[],"cancers":["nasopharyngeal"],"sections":[],"technologies":["oncolytic-virus"],"targets":[],"drugs":[],"companies":["shanghai-sunway-biotech"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo China deep dive","editedOn":"2026-09-16"},"code":"H101","modality":"Oncolytic virus (E1B-deleted adenovirus)","mechanism":"An adenovirus lacking the E1B-55K gene replicates only in cells with a broken p53 pathway, bursting tumour cells and alerting the immune system.","approvals":[{"region":"CN","year":2005,"indication":"Late-stage nasopharyngeal carcinoma, with chemotherapy"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/h101-oncolytic-adenovirus/","neighbours":{"cancer":[{"id":"nasopharyngeal","kind":"cancer","name":"Nasopharyngeal carcinoma","route":"/cancers/nasopharyngeal/"}],"technology":[{"id":"oncolytic-virus","kind":"technology","name":"Oncolytic viruses","route":"/technologies/oncolytic-virus/"}],"company":[{"id":"shanghai-sunway-biotech","kind":"company","name":"Shanghai Sunway Biotech","route":"/companies/shanghai-sunway-biotech/"}]}}