{"entity":{"id":"h4c9","kind":"target","name":"H4C9","aka":["H4 clustered histone 9","Histone H4","H4/m","H4FM","HIST1H4I"],"tldr":"H4C9 (Histone H4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Chronic lymphocytic leukaemia.","summary":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes affected pathway 0.76, animal model 0.46, somatic mutation 0.49). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4793","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4793"},{"label":"UniProt P62805","url":"https://www.uniprot.org/uniprotkb/P62805/entry"},{"label":"NCBI Gene 8294","url":"https://www.ncbi.nlm.nih.gov/gene/8294"},{"label":"Ensembl ENSG00000276180","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000276180"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["cll"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"H4C9","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:4793","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4793","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P62805","url":"https://www.uniprot.org/uniprotkb/P62805/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000276180","url":"https://platform.opentargets.org/target/ENSG00000276180/associations","note":"association with cancer (MONDO_0004992) 0.54;  (GraphQL API, CC0)"},{"label":"IntOGen H4C9","url":"https://www.intogen.org/search?gene=H4C9","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:4793","ensembl":"ENSG00000276180","uniprot":"P62805","entrez":"8294","biology":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Location: Nucleus; Chromosome (UniProt). Locus 6p22.1 (HGNC).","whereFound":["Chronic lymphocytic leukaemia: IntOGen driver in 1 cohort (CLLSLL)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/h4c9/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"cll","kind":"cancer","name":"Chronic lymphocytic leukaemia","route":"/cancers/cll/"}]}}