{"entity":{"id":"hcar3","kind":"target","name":"HCAR3","aka":["hydroxycarboxylic acid receptor 3","Hydroxycarboxylic acid receptor 3","HCA3","HM74","GPR109B"],"tldr":"HCAR3 (Hydroxycarboxylic acid receptor 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.","summary":"G protein-coupled receptor for 3-hydroxyoctanoate, a fatty acid beta-oxidation intermediate. Signals through the inhibitory G(i)/o family of G proteins. Acts as a negative feedback regulator of adipocyte lipolysis, helping to counterbalance prolipolytic signals during physiological or pathological elevations in beta-oxidation.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16824","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16824"},{"label":"UniProt P49019","url":"https://www.uniprot.org/uniprotkb/P49019/entry"},{"label":"NCBI Gene 8843","url":"https://www.ncbi.nlm.nih.gov/gene/8843"},{"label":"Ensembl ENSG00000255398","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000255398"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HCAR3","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:16824","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16824","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P49019","url":"https://www.uniprot.org/uniprotkb/P49019/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen HCAR3","url":"https://www.intogen.org/search?gene=HCAR3","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:16824","ensembl":"ENSG00000255398","uniprot":"P49019","entrez":"8843","biology":"G protein-coupled receptor for 3-hydroxyoctanoate, a fatty acid beta-oxidation intermediate. Signals through the inhibitory G(i)/o family of G proteins. Acts as a negative feedback regulator of adipocyte lipolysis, helping to counterbalance prolipolytic signals during physiological or pathological elevations in beta-oxidation. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Location: Cell membrane (UniProt). Locus 12q24.31 (HGNC).","whereFound":["Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/hcar3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"}]}}