{"entity":{"id":"hck","kind":"target","name":"HCK kinase","aka":[],"tldr":"HCK is a SRC-family kinase of white blood cells that dasatinib and bosutinib inhibit; it drives growth in some leukaemias and in Waldenstrom macroglobulinaemia, where ibrutinib also hits it.","summary":"Haematopoietic cell kinase (HCK) is a SRC-family tyrosine kinase restricted to myeloid cells and B lymphocytes. It is one of the SRC kinases blocked by dasatinib and bosutinib, and in chronic myeloid leukaemia it associates with BCR-ABL and helps drive STAT5 signalling. In Waldenstrom macroglobulinaemia the MYD88 L265P mutation switches HCK on, and part of the activity of ibrutinib in that disease comes from inhibiting HCK as well as BTK. HCK is also being studied as a target in colorectal cancer, where it is active in tumour-associated macrophages.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/HCK","links":[{"label":"UniProt P08631: HCK","url":"https://www.uniprot.org/uniprotkb/P08631/entry"},{"label":"HGNC:4840 HCK","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4840"},{"label":"ChEMBL target CHEMBL3234","url":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL3234"}],"tags":["chembl-gap"],"related":["lyn","btk","src"],"cancers":["cml","waldenstrom","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["dasatinib","bosutinib","ibrutinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"symbol":"HCK","biology":"A non-receptor tyrosine kinase downstream of Fc, integrin and Toll-like receptors in myeloid cells; it activates STAT5, PI3K and MAPK pathways.","whereFound":["Monocytes, macrophages, neutrophils and B cells","CML and Waldenstrom macroglobulinaemia cells"],"targetClass":"kinase","prevalence":[]},"route":"/targets/hck/","neighbours":{"target":[{"id":"btk","kind":"target","name":"BTK (Bruton tyrosine kinase)","route":"/targets/btk/"},{"id":"lyn","kind":"target","name":"LYN kinase","route":"/targets/lyn/"},{"id":"src","kind":"target","name":"SRC family kinases","route":"/targets/src/"}],"cancer":[{"id":"cml","kind":"cancer","name":"Chronic myeloid leukaemia (CML)","route":"/cancers/cml/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"waldenstrom","kind":"cancer","name":"Waldenström macroglobulinaemia","route":"/cancers/waldenstrom/"}],"drug":[{"id":"bosutinib","kind":"drug","name":"Bosutinib","route":"/drugs/bosutinib/"},{"id":"dasatinib","kind":"drug","name":"Dasatinib","route":"/drugs/dasatinib/"},{"id":"ibrutinib","kind":"drug","name":"Ibrutinib","route":"/drugs/ibrutinib/"}]}}