{"entity":{"id":"hdp-103","kind":"drug","name":"HDP-103","aka":["PSMA-ATAC"],"tldr":"HDP-103 is an experimental antibody-drug conjugate with an amanitin payload from Heidelberg Pharma, in preclinical development for metastatic castration-resistant prostate cancer; development is paused.","summary":"HDP-103 (PSMA-ATAC) is an antibody-drug conjugate with an amanitin payload (ATAC) from Heidelberg Pharma, with Huadong Medicine as partner. An amanitin conjugate targeting PSMA for metastatic castration-resistant prostate cancer. Its furthest stage is preclinical development, for metastatic castration-resistant prostate cancer. No clinical trial naming it is registered on ClinicalTrials.gov. Heidelberg will not develop it further itself; working with partner Huadong toward a possible phase 1 in China and seeking partners elsewhere (company page). It has not been shown to work in people.","status":"preclinical","asOf":"2026-11-03","links":[{"label":"Heidelberg Pharma: heidelberg-pharma.com","url":"https://heidelberg-pharma.com/en/research-development/atac-r-projects"},{"label":"Heidelberg Pharma: heidelberg-pharma.com","url":"https://heidelberg-pharma.com/en/research-development/atac-r-projects"}],"tags":["pipeline"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":["psma"],"drugs":[],"companies":["heidelberg-pharma"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"HDP-103","modality":"Antibody-drug conjugate with an amanitin payload (ATAC)","mechanism":"An amanitin conjugate targeting PSMA for metastatic castration-resistant prostate cancer.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/hdp-103/","neighbours":{"target":[{"id":"psma","kind":"target","name":"PSMA","route":"/targets/psma/"}],"company":[{"id":"heidelberg-pharma","kind":"company","name":"Heidelberg Pharma","route":"/companies/heidelberg-pharma/"}]}}