{"entity":{"id":"helix-hereditary-cancer","kind":"drug","name":"Helix Hereditary Comprehensive Cancer Panel","aka":[],"tldr":"Helix's test of 70 genes linked to inherited cancer risk, registered with the US genetic testing registry in 2026.","summary":"Registered in the NIH Genetic Testing Registry as GTR000619734.3 by Helix, Inc. (CLIA 05D2117342; created 20 March 2026, updated 25 March 2026): 70 genes, including the breast, ovarian, Lynch and polyposis genes, BAP1, DICER1, FLCN, MEN1, RET, VHL, the SDH genes, NF1, NF2 and SMARCB1. GTR records it as a test developed by the laboratory; it is not among the FDA-authorised hereditary cancer products.","status":"established","asOf":"2026-11-04","links":[{"label":"NIH Genetic Testing Registry GTR000619734.3","url":"https://www.ncbi.nlm.nih.gov/gtr/tests/619734/"},{"label":"NIH Genetic Testing Registry data file (test_version.gz)","url":"https://ftp.ncbi.nlm.nih.gov/pub/GTR/data/test_version.gz"}],"tags":["test","hereditary"],"related":[],"cancers":[],"sections":[],"technologies":["germline-testing"],"targets":["brca","palb2","mlh1","msh2","bap1","dicer1","flcn","vhl"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["hereditary-cancer-syndromes","lynch-syndrome","birt-hogg-dube-syndrome","bloom-syndrome"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"brand":"Helix Hereditary Comprehensive Cancer Panel","modality":"Germline hereditary cancer sequencing panel (laboratory-developed test)","mechanism":"Next-generation sequencing of 70 hereditary cancer genes in germline DNA.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/helix-hereditary-cancer/","neighbours":{"technology":[{"id":"germline-testing","kind":"technology","name":"Germline (hereditary) testing","route":"/technologies/germline-testing/"}],"target":[{"id":"bap1","kind":"target","name":"BAP1","route":"/targets/bap1/"},{"id":"brca","kind":"target","name":"BRCA1 / BRCA2 (HRD)","route":"/targets/brca/"},{"id":"dicer1","kind":"target","name":"DICER1","route":"/targets/dicer1/"},{"id":"flcn","kind":"target","name":"FLCN","route":"/targets/flcn/"},{"id":"mlh1","kind":"target","name":"MLH1","route":"/targets/mlh1/"},{"id":"msh2","kind":"target","name":"MSH2","route":"/targets/msh2/"},{"id":"palb2","kind":"target","name":"PALB2","route":"/targets/palb2/"},{"id":"vhl","kind":"target","name":"VHL","route":"/targets/vhl/"}],"term":[{"id":"birt-hogg-dube-syndrome","kind":"term","name":"Birt-Hogg-Dubé syndrome","route":"/terms/birt-hogg-dube-syndrome/"},{"id":"bloom-syndrome","kind":"term","name":"Bloom syndrome","route":"/terms/bloom-syndrome/"},{"id":"hereditary-cancer-syndromes","kind":"term","name":"Hereditary cancer syndromes","route":"/terms/hereditary-cancer-syndromes/"},{"id":"lynch-syndrome","kind":"term","name":"Lynch syndrome","route":"/terms/lynch-syndrome/"}]}}