{"entity":{"id":"hepcidin","kind":"term","name":"Hepcidin","aka":[],"tldr":"The liver hormone that controls how much iron the body absorbs and releases. Drugs that mimic it lock iron away so the marrow cannot make excess red cells, the idea behind rusfertide.","summary":"Hepcidin, made in the liver, blocks the iron exporter ferroportin on gut cells and macrophages, lowering the iron available to the bone marrow. In polycythaemia vera hepcidin is inappropriately low, so red-cell production runs unchecked. Rusfertide is an injectable hepcidin mimetic that restores the brake and replaced phlebotomy in most patients in the VERIFY trial; RNA drugs that raise the body's own hepcidin by silencing TMPRSS6 are in early trials.","asOf":"2026-09-16","wikipedia":"https://en.wikipedia.org/wiki/Hepcidin","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Hepcidin"}],"tags":["polycythaemia-vera","mpn"],"related":[],"cancers":["polycythaemia-vera"],"sections":[],"technologies":[],"targets":[],"drugs":["rusfertide"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["verify"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"category":"Biology basics"},"route":"/terms/hepcidin/","neighbours":{"cancer":[{"id":"polycythaemia-vera","kind":"cancer","name":"Polycythaemia vera (PV)","route":"/cancers/polycythaemia-vera/"}],"drug":[{"id":"rusfertide","kind":"drug","name":"Rusfertide","route":"/drugs/rusfertide/"}],"trial":[{"id":"verify","kind":"trial","name":"VERIFY","route":"/trials/verify/"}]}}