{"entity":{"id":"herpud1","kind":"target","name":"HERPUD1","aka":["homocysteine inducible ER protein with ubiquitin like domain 1","Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein","KIAA0025","Mif1","HERPUD1-IT1"],"tldr":"HERPUD1 (Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.56, somatic mutation 0.68).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13744","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13744"},{"label":"UniProt Q15011","url":"https://www.uniprot.org/uniprotkb/Q15011/entry"},{"label":"NCBI Gene 9709","url":"https://www.ncbi.nlm.nih.gov/gene/9709"},{"label":"Ensembl ENSG00000051108","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000051108"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HERPUD1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:13744","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13744","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15011","url":"https://www.uniprot.org/uniprotkb/Q15011/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000051108","url":"https://platform.opentargets.org/target/ENSG00000051108/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"hgnc":"HGNC:13744","ensembl":"ENSG00000051108","uniprot":"Q15011","entrez":"9709","biology":"Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway. Location: Endoplasmic reticulum membrane (UniProt). Locus 16q13 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/herpud1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}