{"entity":{"id":"hhip","kind":"target","name":"HHIP","aka":["hedgehog interacting protein","Hedgehog-interacting protein","FLJ20992"],"tldr":"HHIP (Hedgehog-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.","summary":"Modulates hedgehog signalling in several cell types including brain and lung through direct interaction with members of the hedgehog family.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.96, animal model 0.40, genetic association 0.67).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14866","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14866"},{"label":"UniProt Q96QV1","url":"https://www.uniprot.org/uniprotkb/Q96QV1/entry"},{"label":"NCBI Gene 64399","url":"https://www.ncbi.nlm.nih.gov/gene/64399"},{"label":"Ensembl ENSG00000164161","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164161"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HHIP","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:14866","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14866","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96QV1","url":"https://www.uniprot.org/uniprotkb/Q96QV1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000164161","url":"https://platform.opentargets.org/target/ENSG00000164161/associations","note":"association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: colorectal cancer 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:14866","ensembl":"ENSG00000164161","uniprot":"Q96QV1","entrez":"64399","biology":"Modulates hedgehog signalling in several cell types including brain and lung through direct interaction with members of the hedgehog family. Location: Cell membrane; Secreted; Cytoplasm (UniProt). Locus 4q31.21 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)"],"targetClass":"other","prevalence":[]},"route":"/targets/hhip/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}