{"entity":{"id":"hla-dr","kind":"target","name":"HLA-DR","aka":["HLA-DRA","MHC class II DR"],"tldr":"HLA-DR is the display case that antigen-presenting cells use to show fragments to helper T cells. When monocytes lose it, the immune system is suppressed, which happens in advanced cancer and severe illness.","summary":"HLA-DR is an MHC class II molecule, the structure on which antigen-presenting cells display peptide to CD4 helper T cells, and the alpha chain HLA-DRA is the gene given here. Two uses matter in oncology. It is part of how dendritic cells, B cells and monocytes are identified in a panel; and low HLA-DR on monocytes is a recognised sign of immune suppression, used as a marker of the suppressed myeloid state seen in advanced cancer and critical illness. Myeloid-derived suppressor cells are defined partly by that absence.","asOf":"2026-10-16","wikipedia":"https://en.wikipedia.org/wiki/HLA-DR","links":[{"label":"HGNC:4947","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4947"}],"tags":["immune-marker"],"related":["cd4","hla-a","cd11c"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["antigen-presentation-immunoediting"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"HLA-DRA","role":[],"sources":[],"specificitySources":[],"biology":"MHC class II molecule presenting peptide to CD4 T cells; the alpha chain HLA-DRA is given here.","whereFound":["Dendritic cells","B cells","Monocytes and macrophages","Activated T cells"],"targetClass":"surface-antigen","prevalence":[]},"route":"/targets/hla-dr/","neighbours":{"target":[{"id":"cd11c","kind":"target","name":"CD11c","route":"/targets/cd11c/"},{"id":"cd4","kind":"target","name":"CD4","route":"/targets/cd4/"},{"id":"hla-a","kind":"target","name":"HLA-A","route":"/targets/hla-a/"}],"pathway":[{"id":"antigen-presentation-immunoediting","kind":"pathway","name":"Antigen presentation & immune editing","route":"/pathways/antigen-presentation-immunoediting/"}]}}