{"entity":{"id":"hla-e","kind":"target","name":"HLA-E","aka":["major histocompatibility complex, class I, E","HLA class I histocompatibility antigen, alpha chain E"],"tldr":"HLA-E is the self badge that NKG2A on NK cells reads. Tumours raise it to escape NK cells; monalizumab blocks the reader rather than the badge.","summary":"HLA-E (chromosome 6p22.1) is a non-classical MHC class Ib molecule involved in self versus non-self discrimination that, with beta-2 microglobulin, binds nonamer signal-sequence peptides from classical class Ia molecules and is read by the CD94/NKG2A inhibitory receptor (UniProt P13747). Outside lymphoid tissue its expression is restricted to endothelial cells of all vessel types; in lymphoid organs it is expressed on endothelial venules, B and T cells, monocytes, macrophages, NK cells and megakaryocytes (protein level).","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:4962","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4962"},{"label":"UniProt P13747","url":"https://www.uniprot.org/uniprotkb/P13747/entry"},{"label":"NCBI Gene 3133","url":"https://www.ncbi.nlm.nih.gov/gene/3133"}],"tags":["checkpoint-map"],"related":["klrc1","monalizumab","hla-a"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["cancer-immunity-cycle"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Prevalence not recorded: HGNC and UniProt carry no positivity rates."],"provenance":{"editedBy":"OnCo checkpoint map (HGNC REST, UniProt REST, ClinicalTrials.gov v2)","editedOn":"2026-09-24"},"symbol":"HLA-E","role":["immune-checkpoint"],"sources":[{"label":"HGNC HGNC:4962","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4962","note":"approved symbol, name, aliases and cross-references"},{"label":"UniProt P13747","url":"https://www.uniprot.org/uniprotkb/P13747/entry","note":"protein name, function and tissue specificity"}],"specificitySources":[],"hgnc":"HGNC:4962","ensembl":"ENSG00000204592","uniprot":"P13747","entrez":"3133","biology":"The ligand of NKG2A (KLRC1); the same complex can activate through NKG2C.","whereFound":["Endothelium; lymphoid B and T cells, monocytes, macrophages, NK cells (UniProt P13747)"],"targetClass":"checkpoint","prevalence":[]},"route":"/targets/hla-e/","neighbours":{"target":[{"id":"hla-a","kind":"target","name":"HLA-A","route":"/targets/hla-a/"},{"id":"klrc1","kind":"target","name":"NKG2A (KLRC1)","route":"/targets/klrc1/"}],"drug":[{"id":"monalizumab","kind":"drug","name":"Monalizumab","route":"/drugs/monalizumab/"}],"pathway":[{"id":"cancer-immunity-cycle","kind":"pathway","name":"The cancer-immunity cycle","route":"/pathways/cancer-immunity-cycle/"}],"term":[{"id":"checkpoint","kind":"term","name":"Checkpoint (two meanings)","route":"/terms/checkpoint/"}]}}