{"entity":{"id":"hmga1","kind":"target","name":"HMGA1","aka":["high mobility group AT-hook 1","High mobility group protein HMG-I/HMG-Y","HMGIY"],"tldr":"HMGA1 (High mobility group protein HMG-I/HMG-Y) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.","summary":"HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.99, animal model 0.55, genetic association 0.37, somatic mutation 0.92).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5010","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5010"},{"label":"UniProt P17096","url":"https://www.uniprot.org/uniprotkb/P17096/entry"},{"label":"NCBI Gene 3159","url":"https://www.ncbi.nlm.nih.gov/gene/3159"},{"label":"Ensembl ENSG00000137309","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137309"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HMGA1","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:5010","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5010","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P17096","url":"https://www.uniprot.org/uniprotkb/P17096/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000137309","url":"https://platform.opentargets.org/target/ENSG00000137309/associations","note":"association with cancer (MONDO_0004992) 0.65;  (GraphQL API, CC0)"}],"hgnc":"HGNC:5010","ensembl":"ENSG00000137309","uniprot":"P17096","entrez":"3159","biology":"HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. Location: Nucleus; Chromosome (UniProt). Locus 6p21.31 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/hmga1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}