{"entity":{"id":"hmga2","kind":"target","name":"HMGA2","aka":["high mobility group AT-hook 2","High mobility group protein HMGI-C","HMGIC"],"tldr":"HMGA2 (High mobility group protein HMGI-C) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Oral cavity cancer.","summary":"Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes.\n\nOpen Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 1.00, animal model 0.36, genetic association 0.49, somatic mutation 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5009","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5009"},{"label":"UniProt P52926","url":"https://www.uniprot.org/uniprotkb/P52926/entry"},{"label":"NCBI Gene 8091","url":"https://www.ncbi.nlm.nih.gov/gene/8091"},{"label":"Ensembl ENSG00000149948","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000149948"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer","oral-cavity-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HMGA2","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:5009","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5009","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P52926","url":"https://www.uniprot.org/uniprotkb/P52926/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000149948","url":"https://platform.opentargets.org/target/ENSG00000149948/associations","note":"association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: breast cancer 0.56, oral cavity cancer 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:5009","ensembl":"ENSG00000149948","uniprot":"P52926","entrez":"8091","biology":"Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation. Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner. Location: Nucleus (UniProt). Locus 12q14.3 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)","Oral cavity cancer: Open Targets association 0.52 with oral cavity cancer (MONDO_0005515)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/hmga2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"oral-cavity-cancer","kind":"cancer","name":"Oral cavity cancer (mouth and tongue)","route":"/cancers/oral-cavity-cancer/"}]}}