{"entity":{"id":"hmgcr","kind":"target","name":"HMGCR","aka":["3-hydroxy-3-methylglutaryl-CoA reductase","3-hydroxy-3-methylglutaryl-coenzyme A reductase"],"tldr":"HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Catalyses the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR is the main target of statins, a class of cholesterol-lowering drugs.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.98, animal model 0.39, genetic association 0.39, clinical 0.68).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5006","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5006"},{"label":"UniProt P04035","url":"https://www.uniprot.org/uniprotkb/P04035/entry"},{"label":"NCBI Gene 3156","url":"https://www.ncbi.nlm.nih.gov/gene/3156"},{"label":"Ensembl ENSG00000113161","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113161"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.68. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HMGCR","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:5006","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5006","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P04035","url":"https://www.uniprot.org/uniprotkb/P04035/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000113161","url":"https://platform.opentargets.org/target/ENSG00000113161/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"hgnc":"HGNC:5006","ensembl":"ENSG00000113161","uniprot":"P04035","entrez":"3156","biology":"Catalyses the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR is the main target of statins, a class of cholesterol-lowering drugs. Location: Endoplasmic reticulum membrane; Peroxisome membrane (UniProt). Locus 5q13.3 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/hmgcr/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}