{"entity":{"id":"hnf1b","kind":"target","name":"HNF1B","aka":["HNF1 homeobox B","Hepatocyte nuclear factor 1-beta","LFB3","VHNF1","HNF1beta","MODY5","HNF1β","TCF2"],"tldr":"HNF1B (Hepatocyte nuclear factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma and Ovarian cancer.","summary":"Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene. Transcriptional activity is increased by coactivator PCBD1.\n\nOpen Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes genetic literature 0.92, affected pathway 0.35, literature 0.98, genetic association 0.88, animal model 0.25).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11630","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11630"},{"label":"UniProt P35680","url":"https://www.uniprot.org/uniprotkb/P35680/entry"},{"label":"NCBI Gene 6928","url":"https://www.ncbi.nlm.nih.gov/gene/6928"},{"label":"Ensembl ENSG00000275410","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000275410"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["rcc","ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HNF1B","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:11630","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11630","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P35680","url":"https://www.uniprot.org/uniprotkb/P35680/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000275410","url":"https://platform.opentargets.org/target/ENSG00000275410/associations","note":"association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: renal cell carcinoma 0.71, ovarian cancer 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:11630","ensembl":"ENSG00000275410","uniprot":"P35680","entrez":"6928","biology":"Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene. Transcriptional activity is increased by coactivator PCBD1. Location: Nucleus (UniProt). Locus 17q12 (HGNC).","whereFound":["Renal cell carcinoma: Open Targets association 0.71 with renal cell carcinoma (MONDO_0005086)","Ovarian cancer: Open Targets association 0.54 with ovarian cancer (MONDO_0008170)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/hnf1b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}