{"entity":{"id":"hnf4g","kind":"target","name":"HNF4G","aka":["hepatocyte nuclear factor 4 gamma","Hepatocyte nuclear factor 4-gamma","NR2A2"],"tldr":"HNF4G (Hepatocyte nuclear factor 4-gamma) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Transcription factor. Has a lower transcription activation potential than HNF4-alpha.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.63).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5026","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5026"},{"label":"UniProt Q14541","url":"https://www.uniprot.org/uniprotkb/Q14541/entry"},{"label":"NCBI Gene 3174","url":"https://www.ncbi.nlm.nih.gov/gene/3174"},{"label":"Ensembl ENSG00000164749","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164749"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HNF4G","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:5026","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5026","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q14541","url":"https://www.uniprot.org/uniprotkb/Q14541/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000164749","url":"https://platform.opentargets.org/target/ENSG00000164749/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"hgnc":"HGNC:5026","ensembl":"ENSG00000164749","uniprot":"Q14541","entrez":"3174","biology":"Transcription factor. Has a lower transcription activation potential than HNF4-alpha. Location: Nucleus (UniProt). Locus 8q21.13 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/hnf4g/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}