{"entity":{"id":"hnrnpu","kind":"target","name":"HNRNPU","aka":["heterogeneous nuclear ribonucleoprotein U","Heterogeneous nuclear ribonucleoprotein U","SAF-A","FLJ37978","FLJ30202","HNRPU","HNRNPU-AS1","C1orf199","NCRNA00201"],"tldr":"HNRNPU (Heterogeneous nuclear ribonucleoprotein U) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Burkitt lymphoma.","summary":"DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organisation, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression. Plays a role in the regulation of interphase large-scale gene-rich chromatin organisation through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability. Required for the localisation of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5048","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5048"},{"label":"UniProt Q00839","url":"https://www.uniprot.org/uniprotkb/Q00839/entry"},{"label":"NCBI Gene 3192","url":"https://www.ncbi.nlm.nih.gov/gene/3192"},{"label":"Ensembl ENSG00000153187","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000153187"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["burkitt-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HNRNPU","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:5048","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5048","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q00839","url":"https://www.uniprot.org/uniprotkb/Q00839/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene HNRNPU","url":"https://civicdb.org/features/2682","note":"1 evidence items, 0 assertions, 1 variants; diseases: Burkitt Lymphoma (GraphQL API, CC0)"}],"hgnc":"HGNC:5048","ensembl":"ENSG00000153187","uniprot":"Q00839","entrez":"3192","biology":"DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organisation, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression. Plays a role in the regulation of interphase large-scale gene-rich chromatin organisation through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability. Required for the localisation of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation. Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator. Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner. Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation. Location: Nucleus; Nucleus matrix; Chromosome; Nucleus speckle (UniProt). Locus 1q44 (HGNC).","whereFound":["Burkitt lymphoma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/hnrnpu/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"burkitt-lymphoma","kind":"cancer","name":"Burkitt lymphoma","route":"/cancers/burkitt-lymphoma/"}]}}