{"entity":{"id":"hook3","kind":"target","name":"HOOK3","aka":["hook microtubule tethering protein 3","Protein Hook homolog 3","HK3"],"tldr":"HOOK3 (Protein Hook homolog 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor.\n\nOpen Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.89, genetic association 0.00, somatic mutation 0.85).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:23576","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23576"},{"label":"UniProt Q86VS8","url":"https://www.uniprot.org/uniprotkb/Q86VS8/entry"},{"label":"NCBI Gene 84376","url":"https://www.ncbi.nlm.nih.gov/gene/84376"},{"label":"Ensembl ENSG00000168172","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168172"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HOOK3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:23576","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23576","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q86VS8","url":"https://www.uniprot.org/uniprotkb/Q86VS8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000168172","url":"https://platform.opentargets.org/target/ENSG00000168172/associations","note":"association with cancer (MONDO_0004992) 0.55;  (GraphQL API, CC0)"}],"hgnc":"HGNC:23576","ensembl":"ENSG00000168172","uniprot":"Q86VS8","entrez":"84376","biology":"Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Location: Cytoplasm, cytoskeleton; Golgi apparatus (UniProt). Locus 8p11.21 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/hook3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}