{"entity":{"id":"hot-flushes-on-hormone-therapy","kind":"term","name":"Hot flushes on hormone therapy","aka":["vasomotor symptoms in men","hot flashes"],"tldr":"Sudden waves of heat and sweating caused by losing testosterone: the commonest complaint on hormone therapy for prostate cancer.","summary":"They range from under three minutes of feeling warm to hours of sweating that needs a change of clothes or bedding, and they often disturb sleep. NICE NG131 offers medroxyprogesterone 20 mg a day for an initial 10 weeks and then evaluates it, with cyproterone acetate 50 mg twice a day for 4 weeks as the second option. In a randomised trial of 309 men, the median daily hot-flush score fell by 83.7 percent on medroxyprogesterone, 94.5 percent on cyproterone and 47.2 percent on venlafaxine at one month.","asOf":"2026-09-25","links":[{"label":"NICE NG131: prostate cancer, diagnosis and management","url":"https://www.nice.org.uk/guidance/ng131/chapter/Recommendations"},{"label":"Prostate Cancer UK: hot flushes","url":"https://prostatecanceruk.org/prostate-information-and-support/living-with-prostate-cancer/how-hormone-therapy-affects-you/hot-flushes"},{"label":"Irani et al., venlafaxine, medroxyprogesterone acetate and cyproterone acetate for vasomotor hot flushes (Lancet Oncology 2010)","url":"https://doi.org/10.1016/S1470-2045(09)70338-9"}],"tags":[],"related":[],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Side effects"},"route":"/terms/hot-flushes-on-hormone-therapy/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"term":[{"id":"intermittent-androgen-deprivation","kind":"term","name":"Intermittent androgen deprivation (IAD)","route":"/terms/intermittent-androgen-deprivation/"}]}}