{"entity":{"id":"hoxa11","kind":"target","name":"HOXA11","aka":["homeobox A11","Homeobox protein Hox-A11","HOX1I","HOX1"],"tldr":"HOXA11 (Homeobox protein Hox-A11) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.99, animal model 0.43, genetic association 0.10, somatic mutation 0.93).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5101","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5101"},{"label":"UniProt P31270","url":"https://www.uniprot.org/uniprotkb/P31270/entry"},{"label":"NCBI Gene 3207","url":"https://www.ncbi.nlm.nih.gov/gene/3207"},{"label":"Ensembl ENSG00000005073","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000005073"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HOXA11","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:5101","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5101","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P31270","url":"https://www.uniprot.org/uniprotkb/P31270/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000005073","url":"https://platform.opentargets.org/target/ENSG00000005073/associations","note":"association with cancer (MONDO_0004992) 0.61;  (GraphQL API, CC0)"}],"hgnc":"HGNC:5101","ensembl":"ENSG00000005073","uniprot":"P31270","entrez":"3207","biology":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 7p15.2 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/hoxa11/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}