{"entity":{"id":"hoxa9","kind":"target","name":"HOXA9","aka":["HOX1G","HOX1","homeobox A9"],"tldr":"HOXA9 is an embryonic growth gene that some leukaemias keep switched on so their cells never mature. Menin inhibitors such as revumenib and ziftomenib do not touch HOXA9 itself; they pull menin off the DNA so the gene switches off and the cells grow up.","summary":"HOXA9 (chromosome 7p15.2) is a sequence-specific homeobox transcription factor of the anterior-posterior patterning system that also induces E-selectin and VCAM1 on inflamed endothelium and increases EIF4E-mediated mRNA export and the translation of ODC mRNA (UniProt P31269). The menin-KMT2A pathway record explains its place in leukaemia: KMT2A fusions (infant ALL, about 10% of adult AML) and mutant NPM1 (about 30% of adult AML) are tethered to chromatin through menin and keep HOXA9 and MEIS1 transcribed, holding the cell in a stem-like state. In OnCo, revumenib and ziftomenib occupy the KMT2A-binding pocket of menin, evict the complex, HOXA9 and MEIS1 transcription falls within days and blasts differentiate into mature myeloid cells, with differentiation syndrome as the class toxicity.","asOf":"2026-09-22","links":[{"label":"HGNC HGNC:5109","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5109"},{"label":"UniProt P31269","url":"https://www.uniprot.org/uniprotkb/P31269/entry"},{"label":"NCBI Gene 3205","url":"https://www.ncbi.nlm.nih.gov/gene/3205"}],"tags":["wave5-target"],"related":["revumenib","ziftomenib","menin","kmt2a","npm1","meis1"],"cancers":["aml","all-leukemia","aml-npm1-kmt2a","all-infant"],"sections":[],"technologies":["menin-inhibitors"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["menin-kmt2a","epigenetic-reprogramming","aml-signalling"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Prevalence not recorded in this wave: HGNC and UniProt carry no positivity rates and no other source was consulted."],"provenance":{"editedBy":"OnCo content wave 5 (HGNC REST, UniProt REST, corpus drug and pathway records)","editedOn":"2026-09-22"},"symbol":"HOXA9","hgnc":"HGNC:5109","ensembl":"ENSG00000078399","uniprot":"P31269","entrez":"3205","biology":"HOXA9 is not directly druggable in the corpus; the menin inhibitors act on the scaffold that keeps it expressed, and MEIS1 is its cofactor in the same programme (UniProt O00470).","whereFound":["KMT2A-rearranged acute leukaemia (infant ALL; adult and therapy-related AML)","NPM1-mutant AML"],"targetClass":"transcription","prevalence":[]},"route":"/targets/hoxa9/","neighbours":{"drug":[{"id":"revumenib","kind":"drug","name":"Revumenib","route":"/drugs/revumenib/"},{"id":"ziftomenib","kind":"drug","name":"Ziftomenib","route":"/drugs/ziftomenib/"}],"target":[{"id":"kmt2a","kind":"target","name":"KMT2A (MLL) rearrangement","route":"/targets/kmt2a/"},{"id":"meis1","kind":"target","name":"MEIS1","route":"/targets/meis1/"},{"id":"menin","kind":"target","name":"Menin","route":"/targets/menin/"},{"id":"npm1","kind":"target","name":"NPM1 mutation","route":"/targets/npm1/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"all-infant","kind":"cancer","name":"Infant acute lymphoblastic leukaemia (KMT2A-rearranged, under one year)","route":"/cancers/all-infant/"},{"id":"aml-npm1-kmt2a","kind":"cancer","name":"NPM1-mutated and KMT2A-rearranged acute myeloid leukaemia","route":"/cancers/aml-npm1-kmt2a/"}],"technology":[{"id":"menin-inhibitors","kind":"technology","name":"Menin inhibitors","route":"/technologies/menin-inhibitors/"}],"pathway":[{"id":"aml-signalling","kind":"pathway","name":"Acute myeloid leukaemia (KEGG map)","route":"/pathways/aml-signalling/"},{"id":"epigenetic-reprogramming","kind":"pathway","name":"Epigenetic reprogramming","route":"/pathways/epigenetic-reprogramming/"},{"id":"menin-kmt2a","kind":"pathway","name":"Menin / KMT2A (HOXA9-MEIS1 axis)","route":"/pathways/menin-kmt2a/"}]}}