{"entity":{"id":"hoxb13","kind":"target","name":"HOXB13","aka":["homeobox B13","Homeobox protein Hox-B13"],"tldr":"HOXB13 (Homeobox protein Hox-B13) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Gastric & gastro-oesophageal junction cancer.","summary":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.99, genetic association 0.86, somatic mutation 0.30, animal model 0.38). In OnCo, 1 product record names it (Breast Cancer Index).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5112","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5112"},{"label":"UniProt Q92826","url":"https://www.uniprot.org/uniprotkb/Q92826/entry"},{"label":"NCBI Gene 10481","url":"https://www.ncbi.nlm.nih.gov/gene/10481"},{"label":"Ensembl ENSG00000159184","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000159184"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["prostate","gastric"],"sections":[],"technologies":[],"targets":[],"drugs":["breast-cancer-index"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HOXB13","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:5112","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5112","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92826","url":"https://www.uniprot.org/uniprotkb/Q92826/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene HOXB13","url":"https://civicdb.org/features/8351","note":"2 evidence items, 0 assertions, 1 variants; diseases: Prostate Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000159184","url":"https://platform.opentargets.org/target/ENSG00000159184/associations","note":"association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: gastric cancer 0.52, prostate cancer 0.74 (GraphQL API, CC0)"}],"hgnc":"HGNC:5112","ensembl":"ENSG00000159184","uniprot":"Q92826","entrez":"10481","biology":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA. Location: Nucleus (UniProt). Locus 17q21.32 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.74 with prostate cancer (MONDO_0008315); CIViC evidence names this disease","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.52 with gastric cancer (MONDO_0001056)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/hoxb13/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"drug":[{"id":"breast-cancer-index","kind":"drug","name":"Breast Cancer Index","route":"/drugs/breast-cancer-index/"}]}}