{"entity":{"id":"hoxc13","kind":"target","name":"HOXC13","aka":["homeobox C13","Homeobox protein Hox-C13","HOX3","HOX3G"],"tldr":"HOXC13 (Homeobox protein Hox-C13) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.","summary":"Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes.\n\nOpen Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.93, animal model 0.67, somatic mutation 0.77). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Invasive Breast Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5125","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5125"},{"label":"UniProt P31276","url":"https://www.uniprot.org/uniprotkb/P31276/entry"},{"label":"NCBI Gene 3229","url":"https://www.ncbi.nlm.nih.gov/gene/3229"},{"label":"Ensembl ENSG00000123364","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000123364"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HOXC13","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:5125","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5125","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P31276","url":"https://www.uniprot.org/uniprotkb/P31276/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000123364","url":"https://platform.opentargets.org/target/ENSG00000123364/associations","note":"association with cancer (MONDO_0004992) 0.60;  (GraphQL API, CC0)"},{"label":"IntOGen HOXC13","url":"https://www.intogen.org/search?gene=HOXC13","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:5125","ensembl":"ENSG00000123364","uniprot":"P31276","entrez":"3229","biology":"Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes. Location: Nucleus (UniProt). Locus 12q13.13 (HGNC).","whereFound":["Breast cancer: IntOGen driver in 1 cohort (BRCA)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/hoxc13/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}