{"entity":{"id":"hoxd11","kind":"target","name":"HOXD11","aka":["homeobox D11","Homeobox protein Hox-D11","HOX4","HOX4F"],"tldr":"HOXD11 (Homeobox protein Hox-D11) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.","summary":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.\n\nOpen Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.71, animal model 0.32, genetic association 0.37, somatic mutation 0.94).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5134","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5134"},{"label":"UniProt P31277","url":"https://www.uniprot.org/uniprotkb/P31277/entry"},{"label":"NCBI Gene 3237","url":"https://www.ncbi.nlm.nih.gov/gene/3237"},{"label":"Ensembl ENSG00000128713","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128713"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HOXD11","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:5134","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5134","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P31277","url":"https://www.uniprot.org/uniprotkb/P31277/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000128713","url":"https://platform.opentargets.org/target/ENSG00000128713/associations","note":"association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: colorectal cancer 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:5134","ensembl":"ENSG00000128713","uniprot":"P31277","entrez":"3237","biology":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 2q31.1 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/hoxd11/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}