{"entity":{"id":"hoxd13","kind":"target","name":"HOXD13","aka":["homeobox D13","Homeobox protein Hox-D13","HOX4I"],"tldr":"HOXD13 (Homeobox protein Hox-D13) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, animal model 0.82, genetic association 0.00, somatic mutation 0.93).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5136","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5136"},{"label":"UniProt P35453","url":"https://www.uniprot.org/uniprotkb/P35453/entry"},{"label":"NCBI Gene 3239","url":"https://www.ncbi.nlm.nih.gov/gene/3239"},{"label":"Ensembl ENSG00000128714","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128714"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HOXD13","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:5136","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5136","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P35453","url":"https://www.uniprot.org/uniprotkb/P35453/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000128714","url":"https://platform.opentargets.org/target/ENSG00000128714/associations","note":"association with cancer (MONDO_0004992) 0.61;  (GraphQL API, CC0)"}],"hgnc":"HGNC:5136","ensembl":"ENSG00000128714","uniprot":"P35453","entrez":"3239","biology":"Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 2q31.1 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/hoxd13/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}