{"entity":{"id":"hras","kind":"target","name":"HRAS","aka":["HRas proto-oncogene, GTPase","GTPase HRas","HRAS1"],"tldr":"HRAS (GTPase HRas) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Thyroid cancer, Sarcomas and 5 more.","summary":"Signal transducer in the Ras-MAPK signalling pathway that regulates cell proliferation and survival. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Recognised by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex.\n\nCIViC holds 24 clinical evidence items and 2 assertions across 12 variants, naming Vemurafenib, Selumetinib, Cetuximab and Erlotinib and others. Open Targets scores its association with cancer at 0.90 (direct and indirect evidence; datatypes genetic literature 0.79, clinical 0.16, affected pathway 0.90, literature 0.98, genetic association 0.86, somatic mutation 0.97, animal model 0.43). IntOGen calls it a driver in 23 cohorts (23 activating, 0 loss-of-function), covering Angiosarcoma, Bladder Urothelial Carcinoma, Invasive Breast Carcinoma, Colorectal Adenocarcinoma, Cutaneous Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma and others. In OnCo, 1 product record names it (JYP0015).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5173","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5173"},{"label":"UniProt P01112","url":"https://www.uniprot.org/uniprotkb/P01112/entry"},{"label":"NCBI Gene 3265","url":"https://www.ncbi.nlm.nih.gov/gene/3265"},{"label":"Ensembl ENSG00000174775","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000174775"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["urothelial","thyroid","sarcoma","head-and-neck","neuroendocrine","prostate","colorectal","breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["jyp0015"],"companies":[],"institutions":[],"pathways":["bladder-cancer-signalling"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.16; IntOGen calls it an activating (Act) driver in 23 cohorts; CIViC holds 24 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Skin Squamous Cell Carcinoma; Follicular Thyroid Carcinoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HRAS","role":["drug-target","oncogene-driver","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:5173","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5173","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P01112","url":"https://www.uniprot.org/uniprotkb/P01112/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene HRAS","url":"https://civicdb.org/features/2747","note":"24 evidence items, 2 assertions, 12 variants; diseases: Skin Squamous Cell Carcinoma, Cancer, Colorectal Cancer, Head And Neck Squamous Cell Carcinoma, Head And Neck Cancer and 4 more (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000174775","url":"https://platform.opentargets.org/target/ENSG00000174775/associations","note":"association with cancer (MONDO_0004992) 0.90; per-cancer scores at or above 0.5: urinary bladder cancer 0.79, head and neck squamous cell carcinoma 0.66, sarcoma 0.67, thyroid cancer 0.77, neuroendocrine neoplasm 0.64, skin cancer 0.54 (GraphQL API, CC0)"},{"label":"IntOGen HRAS","url":"https://www.intogen.org/search?gene=HRAS","note":"driver in 23 cohorts (Act 23, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:5173","ensembl":"ENSG00000174775","uniprot":"P01112","entrez":"3265","biology":"Signal transducer in the Ras-MAPK signalling pathway that regulates cell proliferation and survival. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Recognised by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Location: Cell membrane; Golgi apparatus; Golgi apparatus membrane; Nucleus (UniProt). Locus 11p15.5 (HGNC).","whereFound":["Bladder & urothelial cancer: Open Targets association 0.79 with urinary bladder cancer (MONDO_0001187); CIViC evidence names this disease","Thyroid cancer: Open Targets association 0.77 with thyroid cancer (MONDO_0002108); CIViC evidence names this disease","Sarcomas: Open Targets association 0.67 with sarcoma (MONDO_0005089)","Head and neck squamous cell carcinoma: Open Targets association 0.66 with head and neck squamous cell carcinoma (MONDO_0010150); CIViC evidence names this disease","Neuroendocrine tumours: Open Targets association 0.64 with neuroendocrine neoplasm (MONDO_0019496)","Prostate cancer: IntOGen driver in 4 cohorts (PRAD, PROSTATE)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/hras/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}],"drug":[{"id":"jyp0015","kind":"drug","name":"JYP0015","route":"/drugs/jyp0015/"}],"pathway":[{"id":"bladder-cancer-signalling","kind":"pathway","name":"Bladder cancer (KEGG map)","route":"/pathways/bladder-cancer-signalling/"}]}}