{"entity":{"id":"hsp90ab1","kind":"target","name":"HSP90AB1","aka":["heat shock protein 90 alpha family class B member 1","Heat shock protein HSP 90-beta","HSPC2","HSPCB"],"tldr":"HSP90AB1 (Heat shock protein HSP 90-beta) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.","summary":"Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Melanoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5258","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5258"},{"label":"UniProt P08238","url":"https://www.uniprot.org/uniprotkb/P08238/entry"},{"label":"NCBI Gene 3326","url":"https://www.ncbi.nlm.nih.gov/gene/3326"},{"label":"Ensembl ENSG00000096384","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000096384"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HSP90AB1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:5258","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5258","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P08238","url":"https://www.uniprot.org/uniprotkb/P08238/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen HSP90AB1","url":"https://www.intogen.org/search?gene=HSP90AB1","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:5258","ensembl":"ENSG00000096384","uniprot":"P08238","entrez":"3326","biology":"Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. Location: Cytoplasm; Melanosome; Nucleus; Secreted (UniProt). Locus 6p21.1 (HGNC).","whereFound":["Melanoma: IntOGen driver in 1 cohort (MEL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/hsp90ab1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}]}}