{"entity":{"id":"hsp90b1","kind":"target","name":"HSP90B1","aka":["heat shock protein 90 beta family member 1","Endoplasmin","GP96","GRP94","TRA1"],"tldr":"HSP90B1 (Endoplasmin) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport. Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway. When associated with CNPY3, required for proper folding of Toll-like receptors.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Temozolomide and Onalespib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12028","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12028"},{"label":"UniProt P14625","url":"https://www.uniprot.org/uniprotkb/P14625/entry"},{"label":"NCBI Gene 7184","url":"https://www.ncbi.nlm.nih.gov/gene/7184"},{"label":"Ensembl ENSG00000166598","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166598"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Glioma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HSP90B1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:12028","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12028","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P14625","url":"https://www.uniprot.org/uniprotkb/P14625/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene HSP90B1","url":"https://civicdb.org/features/5876","note":"1 evidence items, 0 assertions, 1 variants; diseases: Glioma (GraphQL API, CC0)"}],"hgnc":"HGNC:12028","ensembl":"ENSG00000166598","uniprot":"P14625","entrez":"7184","biology":"ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport. Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway. When associated with CNPY3, required for proper folding of Toll-like receptors. Promotes folding and trafficking of TLR4 to the cell surface. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10. Location: Endoplasmic reticulum lumen; Sarcoplasmic reticulum lumen; Melanosome (UniProt). Locus 12q23.3 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/hsp90b1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}