{"entity":{"id":"hspb1","kind":"target","name":"HSPB1","aka":["heat shock protein family B (small) member 1","Heat shock protein beta-1","HSP27","HSP28","Hs.76067","Hsp25","CMT2F"],"tldr":"HSPB1 (Heat shock protein beta-1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.","summary":"Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organisation. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Gemcitabine.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5246","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5246"},{"label":"UniProt P04792","url":"https://www.uniprot.org/uniprotkb/P04792/entry"},{"label":"NCBI Gene 3315","url":"https://www.ncbi.nlm.nih.gov/gene/3315"},{"label":"Ensembl ENSG00000106211","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106211"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HSPB1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:5246","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5246","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P04792","url":"https://www.uniprot.org/uniprotkb/P04792/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene HSPB1","url":"https://civicdb.org/features/2784","note":"1 evidence items, 0 assertions, 1 variants; diseases: Pancreatic Ductal Adenocarcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:5246","ensembl":"ENSG00000106211","uniprot":"P04792","entrez":"3315","biology":"Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organisation. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. Location: Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 7q11.23 (HGNC).","whereFound":["Pancreatic ductal adenocarcinoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/hspb1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}