{"entity":{"id":"htan","kind":"collection","name":"Human Tumor Atlas Network (HTAN)","aka":["HTAN","NCI Human Tumor Atlas Network"],"tldr":"A US National Cancer Institute project that builds detailed maps of human tumours, cell by cell and in three dimensions, to show how a cancer changes from an early lesion to advanced disease. Researchers anywhere can download most of the processed data.","summary":"HTAN is an NCI-funded network, part of the Cancer Moonshot, that constructs three-dimensional atlases of the cellular, morphological and molecular features of human cancers as they evolve from precancerous lesions to advanced disease. The founding paper (Rozenblatt-Rosen et al., Cell 2020) set out the aim: to use single-cell genomics and spatial multiplex in situ methods to chart transitions such as tumour initiation, local expansion, metastasis and therapeutic resistance, complementing healthy-organ atlases and earlier bulk-sequencing cancer genomics, and to integrate longitudinal atlases with clinical outcomes in search of predictive biomarkers and therapeutically relevant cell states and interactions.\n\nThe portal's data release V8.0 (last updated 3 August 2026) covers 15 atlases, 20 organs, 2,383 cases and 10,608 biospecimens; the site announced the first data release of HTAN Phase 2. Access is tiered: processed level 3 and 4 files are open on Synapse, imaging is open under CC BY 4.0 in the Imaging Data Commons, and raw level 1 and 2 sequencing is controlled through dbGaP study phs002371.","asOf":"2026-11-03","links":[{"label":"Human Tumor Atlas Network","url":"https://humantumoratlas.org"},{"label":"HTAN data access","url":"https://humantumoratlas.org/data-access"},{"label":"NCI Cancer Moonshot progress (HTAN)","url":"https://www.cancer.gov/research/progress/moonshot-cancer-initiative"},{"label":"Rozenblatt-Rosen et al., The Human Tumor Atlas Network, Cell 2020 (PMID 32302568)","url":"https://doi.org/10.1016/j.cell.2020.03.053"}],"tags":[],"related":["single-cell-rna-seq","spatial-transcriptomics-platforms"],"cancers":[],"sections":[],"technologies":["single-cell-spatial","spatial-transcriptomics"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["The corpus also has an htan row in src/data/data-sources.ts (status candidate) and the htan-portal project in src/data/open-source.ts; this collection record is the reader-facing page for the atlas itself.","Funding totals and the number of funded atlas centres per phase were not stated on the pages read and are left out."],"url":"https://humantumoratlas.org","holds":"Single-cell, spatial, imaging and clinical data from human tumours and precancerous lesions, organised as atlases that follow cancers from precancer to advanced disease; data release V8.0 (last updated 2026-08-03) lists 15 atlases, 20 organs, 2,383 cases and 10,608 biospecimens.","license":"Mixed: processed level 3 and 4 data open on Synapse; imaging open under CC BY 4.0 on the NCI Imaging Data Commons; level 1 and 2 sequencing access-controlled through dbGaP (phs002371) on the Seven Bridges Cancer Genomics Cloud","maintainer":"National Cancer Institute (Cancer Moonshot)"},"route":"/collections/htan/","neighbours":{"term":[{"id":"single-cell-rna-seq","kind":"term","name":"Single-cell RNA sequencing (scRNA-seq, 10x Chromium)","route":"/terms/single-cell-rna-seq/"},{"id":"spatial-transcriptomics-platforms","kind":"term","name":"Spatial transcriptomics platforms (Visium HD, Xenium, MERFISH, CosMx, CODEX)","route":"/terms/spatial-transcriptomics-platforms/"}],"technology":[{"id":"single-cell-spatial","kind":"technology","name":"Single-cell & spatial profiling","route":"/technologies/single-cell-spatial/"},{"id":"spatial-transcriptomics","kind":"technology","name":"Spatial transcriptomics","route":"/technologies/spatial-transcriptomics/"}]}}